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Article

Genetic analysis of an in vitro model system for human papillomavirus type 16-associated tumorigenesis.

Cancer research - 1 Nov 1994

Seagon S, Dürst M

Abstract excerpt

We have investigated the genetic basis for malignant progression of an human papillomavirus type 16 immortalized human keratinocyte cell line (HPKIA) by somatic cell fusion. In this cell culture model system for human papillomavirus type 16-associated tumorigenesis, early passage cells (HPKIA-nt) are nontumorigenic, whereas gamma-irradiated late passage cells (HPKIA-t) are tumorigenic when tested in nude mice....

Topics

Animals
Cell Fusion
Cell Line
Cell Transformation, Viral
DNA, Viral
Female
Humans
Hybrid Cells
Keratinocytes
Mice
Mice, Nude
Papillomaviridae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Tumor Cells, Cultured

Uterine Cervical Neoplasms

Source

Identifiers

PMID: 7923202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7923202-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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