Altered expression of proliferation and differentiation markers in human papillomavirus 16 and 18 immortalized epithelial cells grown in organotypic culture.

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Article

Altered expression of proliferation and differentiation markers in human papillomavirus 16 and 18 immortalized epithelial cells grown in organotypic culture.

The American journal of pathology - 1 Jan 1992

Merrick D T, Blanton R A, Gown A M, McDougall J K

Abstract excerpt

The patterns of expression of keratins K1 and K8, filaggrin, and the proliferation-associated protein, proliferating cell nuclear antigen (PCNA), were studied in normal and human papillomavirus (HPV) 16 or 18 immortalized keratinocyte cell lines grown on organotypic raft cultures. Normal keratinocytes produced an epithelial sheet that closely resembled epidermis in vivo, characterized by lack of K8 expression,...

Topics

Antigens, Differentiation
Cell Differentiation
Cell Division
Cells, Cultured
Epithelial Cells
Epithelium
Filaggrin Proteins
Humans
Immunohistochemistry
Intermediate Filament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Keratinocytes

Keratins

Male

Nuclear Proteins

Papillomaviridae

Phenotype

Proliferating Cell Nuclear Antigen

Source

Open in PubMed Open full text

Identifiers

PMID: 1370596
PMCID: PMC1886258

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1370596-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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