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Myc and Human Papillomavirus Type 16 E7 Genes Cooperate To Immortalize Human Keratinocytes

5 Sept 2007

Abstract excerpt

The E6 protein of the oncogenic human papillomaviruses (HPVs), in combination with the E7 protein, is essential for the efficient immortalization of human foreskin keratinocytes (HFKs). Since we recently demonstrated that E6 activates the human telomerase reverse transcriptase (hTERT) promoter via a Myc-dependent mechanism, we speculated that overexpressed Myc might be able to substitute for E6 in cell...

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PMID: 17804506
DOI: 10.1128/jvi.00669-07

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Myc and Human Papillomavirus Type 16 E7 Genes Cooperate To Immortalize Human KeratinocytesPMID 17804506Read ↗

Cell-Restricted Immortalization by Human Papillomavirus Correlates with Telomerase Activation and Engagement of the hTERT Promoter by MycSemantic proximity Read ↗

HPV E6 protein interacts physically and functionally with the cellular telomerase complexSemantic proximity Read ↗

Telomerase activation by the E6 gene product of human papillomavirus type 16.Semantic proximity Read ↗

HPV16 E7 Protein and hTERT Proteins Defective for Telomere Maintenance Cooperate to Immortalize Human KeratinocytesSemantic proximity Read ↗

Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.Semantic proximity Read ↗

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.Semantic proximity Read ↗

The Human Papillomavirus Type 16 E6 and E7 Oncoproteins Dissociate Cellular Telomerase Activity from the Maintenance of Telomere LengthSemantic proximity Read ↗

Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding SitesSemantic proximity Read ↗

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cellsSemantic proximity Read ↗

Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 OncoproteinSemantic proximity Read ↗

The E5 Gene of HPV-16 Enhances Keratinocyte Immortalization by Full-Length DNASemantic proximity Read ↗

The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cellsSemantic proximity Read ↗

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