Article
An A gamma globin promoter (four base-pair deletion) mutant shows linked polymorphic changes throughout the A gamma gene.
Experimental hematology - 1 Mar 1992
Harvey M P, Motum P, Lindeman R, Trent R J
Abstract excerpt
The A gamma fetal globin genes from a large Australian kindred with nondeletional A gamma hereditary persistence of fetal hemoglobin (HPFH) were cloned and sequenced. The -198 T----C mutation (British type HPFH) was demonstrated upstream of the A gamma gene on one allele. On the other allele, a 4...
Topics
- Alleles
- Base Sequence
- Chromosome Deletion
- DNA, Neoplasm
- Exons
- Fetal Hemoglobin
- Globins
- Hemoglobinopathies
- Heterozygote
- Humans
- Leukemia, Erythroblastic, Acute
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Tumor Cells, Cultured