Article
Natural analogue peptides of an HIV-1 GP120 T-helper epitope antagonize response of GP120-specific human CD4 T-cell clones.
Journal of acquired immune deficiency syndromes (1999) - 1 Jan 2000
Fenoglio D, Li Pira G, Lozzi L, Bracci L, Saverino D, Terranova P, Bottone L, Lantero S, Megiovanni A, Merlo A, Manca F
Abstract excerpt
Neutralizing antibodies and specific cytotoxic T lymphocytes (CTL) may contribute to controlling viral spread, and ideally, to virus clearance in HIV infection. Both effector mechanisms depend on specific CD4 T-helper (Th) cells. Nevertheless, HIV hypervariability facilitates appearance of escape mutants for antibodies and for CTL responses. Here we also show that natural mutations (i.e., from sequences of...
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