Article
Immunogenic HIV variant peptides that bind to HLA-B8 can fail to stimulate cytotoxic T lymphocyte responses.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1995
McAdam S, Klenerman P, Tussey L, Rowland-Jones S, Lalloo D, Phillips R, Edwards A, Giangrande P, Brown A L, Gotch F
Abstract excerpt
Cytotoxic T lymphocyte responses in HIV infection can be impaired through variation in the epitope regions of viral proteins such as a gag. We report here an analysis of variant epitope peptides in three gag epitopes presented by HLA B8. Fifteen variant peptides were examined for their binding to HLA-B8; all but one bound at concentrations comparable to known epitopes. All except two of those that bound could be...
Topics
- Animals
- Antigens, Viral
- Base Sequence
- CHO Cells
- Cricetinae
- Cytotoxicity Tests, Immunologic
- Epitopes
- Female
- Gene Products, gag
- Genetic Variation
- HIV Antigens