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Article

The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.

Molecular and cellular biology - 1 Jan 2012

Schillewaert Stéphanie, Wacheul Ludivine, Lhomme Frédéric, Lafontaine Denis L J

Abstract excerpt

Ribosome synthesis entails the formation of mature rRNAs from long precursor molecules, following a complex pre-rRNA processing pathway. Why the generation of mature rRNA ends is so complicated is unclear. Nor is it understood how pre-rRNA processing is coordinated at distant sites on pre-rRNA molecules. Here we characterized, in budding yeast and human cells, the evolutionarily conserved protein Las1. We found...

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Identifiers

PMID: 22083961
DOI: 10.1128/MCB.06019-11
PMCID: PMC3255765

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.PMID 22083961Read ↗

The 5' end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site.Semantic proximity Read ↗

Role of the ITS2-proximal stem and evidence for indirect recognition of processing sites in pre-rRNA processing in yeast.Semantic proximity Read ↗

Yeast polypeptide exit tunnel ribosomal proteins L17, L35 and L37 are necessary to recruit late-assembling factors required for 27SB pre-rRNA processing.Semantic proximity Read ↗

Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 of yeast pre-rRNA that depends on Rex4p.Semantic proximity Read ↗

The nucleolar protein NOL12 is required for 5' end processing of large ribosomal subunit rRNA precursors in ArabidopsisSemantic proximity Read ↗

The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction with trans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiae pre-rRNA.Semantic proximity Read ↗

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The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.Semantic proximity Read ↗

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