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Article

Two-locus linkage analysis in multiple sclerosis (MS).

Genomics - 15 Jan 1994

Tienari P J, Terwilliger J D, Ott J, Palo J, Peltonen L

Abstract excerpt

One of the major challenges in genetic linkage analyses is the study of complex diseases. We demonstrate here the use of two-locus linkage analysis in multiple sclerosis (MS), a multifactorial disease with a complex mode of inheritance. In a set of Finnish multiplex families, we have previously found evidence for linkage between MS susceptibility and two independent loci, the myelin basic protein gene (MBP) on...

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Identifiers

PMID: 7514567
DOI: 10.1006/geno.1994.1064

Genes

MBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene.Semantic proximity Read ↗

A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility.Semantic proximity Read ↗

Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44.Semantic proximity Read ↗

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