Two-locus linkage analysis in multiple sclerosis (MS).

doi:10.1006/geno.1994.1064

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Article

Two-locus linkage analysis in multiple sclerosis (MS).

Genomics - 15 Jan 1994

Tienari P J, Terwilliger J D, Ott J, Palo J, Peltonen L

Abstract excerpt

One of the major challenges in genetic linkage analyses is the study of complex diseases. We demonstrate here the use of two-locus linkage analysis in multiple sclerosis (MS), a multifactorial disease with a complex mode of inheritance. In a set of Finnish multiplex families, we have previously f...

Topics

Alleles
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 6
Epistasis, Genetic
Finland
Genes
Genetic Linkage
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ alpha-Chains
Humans
Lod Score
Major Histocompatibility Complex
Multiple Sclerosis
Myelin Basic Protein

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