Article
A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility.
Brain : a journal of neurology - 1 Jun 2002
Sawcer Stephen, Maranian Mel, Setakis Efrosini, Curwen Val, Akesson Eva, Hensiek Anke, Coraddu Francesca, Roxburgh Richard, Sawcer David, Gray Julia, Deans Jackie, Goodfellow Peter N, Walker Neil, Clayton David, Compston Alastair
Abstract excerpt
Linkage analysis in multiplex families has provisionally identified several genomic regions where genes influencing susceptibility to multiple sclerosis are likely to be located. It is anticipated that association mapping will provide a higher degree of resolution, but this more powerful approach is limited by the substantial genotyping effort required. Here, we describe the first use of DNA pooling to screen the...
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