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Article

Effects of lymphocyte subpopulations on the clonal assay of HPRT mutants: occupational exposure to cytostatic drugs.

Mutation research - 1 May 1994

Dubeau H, Zazi W, Baron C, Messing K

Abstract excerpt

The mutagenic effect of occupational exposure to antineoplastic agents was studied in chemotherapy nurses and pharmacists using the T-lymphocyte clonal assay. A significant increase in mutant frequency was observed compared to controls. However, in the present study, cloning efficiency without selection (CEU) was significantly reduced in exposed personnel raising the possibility of an overestimation of the...

Topics

Adult
Antineoplastic Agents
Clone Cells
Health Personnel
Humans
Hypoxanthine Phosphoribosyltransferase
Middle Aged
Mutagenicity Tests
Mutation
Nurses
Occupational Exposure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacists

Quebec

T-Lymphocyte Subsets

Source

Identifiers

PMID: 7513065
DOI: 10.1016/0165-1218(94)90039-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7513065-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Effects of lymphocyte subpopulations on the clonal assay of HPRT mutants: occupational exposure to cytostatic drugs.PMID 7513065Read ↗

Use of the clonal assay for the measurement of frequencies of HPRT mutants in T-lymphocytes from five control populations.Semantic proximity Read ↗

Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations.Semantic proximity Read ↗

Occupational exposure to antineoplastic agents induces a high level of chromosome damage. Lack of an effect of GST polymorphisms.Semantic proximity Read ↗

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Molecular biomonitoring of a population of nurses handling antineoplastic drugs.Semantic proximity Read ↗

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