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Article

Use of a T-lymphocyte clonal assay for determining HPRT mutant frequencies in individual rats.

Mutation research - 1 Jun 1992

van Dam F J, Natarajan A T, Tates A D

Abstract excerpt

Conditions for detection and isolation of HPRT- mutants in cloned rat T-lymphocytes from individual adult Lewis rats were determined. Similar to cloning of human T-cells, best results were obtained with lectin (PHA)-primed T-lymphocytes of rats. High cloning efficiencies, occasionally exceeding 50%, could be obtained when the target cells employed were isolated from cervical lymph nodes. Feeder cells used were...

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PMID: 1378196
DOI: 10.1016/0165-1161(92)90018-h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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