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Article

Frequencies of HPRT mutants and micronuclei in lymphocytes of cancer patients under chemotherapy: a prospective study.

Mutation research - 1 May 1994

Tates A D, van Dam F J, Natarajan A T, Zwinderman A H, Osanto S

Abstract excerpt

Fifteen cancer patients, including 10 testicular carcinoma patients, were treated with several types of combination chemotherapy. Blood samples were collected before, during and after chemotherapy. Subsequently, lymphocytes were analyzed for frequencies of HPRT mutants (MF) and micronuclei (MNF). Significantly elevated MFs were detected in eight patients. Mean expression time (+/- SD) for mutations was 98 +/- 54...

Topics

Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Cells, Cultured
DNA Damage
Female
Humans
Hypoxanthine Phosphoribosyltransferase
Lymphocytes
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Micronucleus Tests

Middle Aged

Mutation

Neoplasms

Prospective Studies

Source

Identifiers

PMID: 7513809
DOI: 10.1016/0027-5107(94)90303-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7513809-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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