Does the gender difference in interferon production seen in picornavirus-infected spleen cell cultures from ICR Swiss mice have any in vivo significance?

doi:10.1089/jir.1993.13.387

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Article

Does the gender difference in interferon production seen in picornavirus-infected spleen cell cultures from ICR Swiss mice have any in vivo significance?

Journal of interferon research - 1 Dec 1993

Curiel R E, Miller M H, Ishikawa R, Thomas D C, Bigley N J

Abstract excerpt

Splenocyte cultures from female ICR Swiss mice produced greater interferon (IFN) levels, particularly IFN-gamma, than did cultures from males by 12 h post-infection (pi) with the D variant of encephalomyocarditis virus (EMCV-D). This early IFN-gamma is produced by natural killer (NK)-like cells and is dependent on plastic adherent cells and IFN-alpha/beta. In this study, we evaluated the significance of this...

Topics

Animals
Cardiovirus Infections
Cells, Cultured
Encephalomyocarditis virus
Female
Flow Cytometry
Immune Sera
Immunity, Innate
Interferons
Leukocytes, Mononuclear
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred ICR

Pancreas

Perfusion

Phenotype

Sex Factors

Spleen

Source

Open in PubMed

Identifiers

PMID: 7512115
DOI: 10.1089/jir.1993.13.387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7512115-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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