Article
Comparison of dynamic expressions of Tim-3 and PD-1 in the brains between toxoplasmic encephalitis-resistant BALB/c and -susceptible C57BL/6 mice.
Parasitology research - 1 Apr 2014
Wu Bin, Fu Xiaoyin, Huang Bo, Tong Xinxin, Zheng Huanqin, Huang Shiguang, Lu Fangli
Abstract excerpt
T cells and IFN-γ are essential for controlling the reactivation of toxoplasmic encephalitis (TE), regardless of whether mice are susceptible or resistant to TE. It has been demonstrated that CD8(+) T cells exhausted in chronic Toxoplasma gondii infection result in TE reactivation in C57BL/6 mice. However, this phenomenon had not been reported in genetically TE-resistant BALB/c mice. To explore the immune...
Topics
- Animals
- B7-H1 Antigen
- Brain
- Disease Resistance
- Female
- Galectins
- Genetic Predisposition to Disease
- Hepatitis A Virus Cellular Receptor 2
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Programmed Cell Death 1 Ligand 2 Protein
- Programmed Cell Death 1 Receptor