Cytokines produced early in picornavirus infection reflect resistance or susceptibility to disease.

doi:10.1089/jir.1998.18.587

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Article

Cytokines produced early in picornavirus infection reflect resistance or susceptibility to disease.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Aug 1998

Curiel R E, Mason K M, Dryden T D, Maurer M J, Bigley N J

Abstract excerpt

Gender bias favoring female resistance to picornavirus disease is not seen in ICR Swiss mice following infection with the MM strain of encephalomyocarditis virus (EMCV) (causing encephalitis and death) as it is with D variant of EMCV (causing diabetes in males). To define this difference, an in vitro virus-infected splenocyte culture system was used to explore virus effects on lymphoid cells. Infected and...

Topics

Adjuvants, Immunologic
Animals
Cells, Cultured
Diabetes Mellitus, Experimental
Female
Genetic Predisposition to Disease
Histocompatibility Antigens Class II
Interferon Inducers
Interferon-gamma
Interleukin-10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred ICR

Picornaviridae Infections

Poly I-C

Spleen

Time Factors

Source

Open in PubMed

Identifiers

PMID: 9726440
DOI: 10.1089/jir.1998.18.587

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