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Article

Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations.

The Journal of experimental medicine - 2 Nov 1998

Selin L K, Varga S M, Wong I C, Welsh R M

Abstract excerpt

A basic principle of immunology is that prior immunity results in complete protection against a homologous agent. In this study, we show that memory T cells specific to unrelated viruses may alter the host's primary immune response to a second virus. Studies with a panel of heterologous viruses, including lymphocytic choriomeningitis (LCMV), Pichinde (PV), vaccinia (VV), and murine cytomegalo (MCMV) viruses...

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Identifiers

PMID: 9802982
DOI: 10.1084/jem.188.9.1705
PMCID: PMC2212518

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