Anti-idiotypic antibodies to the third variable domain of gp120 induce an anti-HIV-1 antibody response in mice.

doi:10.1006/viro.1994.1176

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Article

Anti-idiotypic antibodies to the third variable domain of gp120 induce an anti-HIV-1 antibody response in mice.

Virology - 1 Apr 1994

Boudet F, Theze J, Zouali M

Abstract excerpt

We tested the potential of anti-idiotypic antibodies to function as molecular mimics of a neutralizing epitope of the human immunodeficiency virus (HIV). Three monoclonal antibodies to the third variable domain (V3) of gp120 from the HIV-1LAI isolate were raised in a BALB/c mouse. They bound gp120LAI with high affinity (K congruent to 10(-11) M), immunoprecipitated viral gp120LAI, recognized HIVLAI-infected cells...

Topics

Animals
Antibodies, Anti-Idiotypic
Antibodies, Monoclonal
Antibody Specificity
Binding, Competitive
Epitopes
Female
Genetic Variation
HIV Antibodies
HIV Envelope Protein gp120
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunization

Immunoglobulin Isotypes

Mice

Mice, Inbred BALB C

Neutralization Tests

Rabbits

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 7510435
DOI: 10.1006/viro.1994.1176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7510435-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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