Symmetry and asymmetry in idiotypic interactions.

Abstract excerpt

At the level of antibody molecules, the partners in an idiotypic interaction are functionally equivalent, and the distinction between "idiotype" and "anti-idiotype" is merely operational. This point must be taken into account in the interpretation of regulatory experiments with "idiotypic" and "antiidiotypic" antibodies. Indeed, consistent interpretations of certain sets of data can be obtained if "idiotype" and...

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