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Article

Autologous antibody response against the principal neutralizing domain of human immunodeficiency virus type 1 isolated from infected humans.

Journal of virology - 1 Mar 1993

Holmbäck K, Kusk P, Hulgaard E F, Bugge T H, Scheibel E, Lindhardt B O

Abstract excerpt

High titers of neutralizing antibodies in human immunodeficiency virus type 1 (HIV-1) infection are directed primarily against the third hypervariable domain (V3) of the virion envelope glycoprotein gp120. This region has been designated the principal neutralizing domain of HIV-1. Because the frequency and significance of autologous V3 antibodies in natural infection are not fully clarified, we have cloned,...

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Identifiers

PMID: 8437232
DOI: 10.1128/JVI.67.3.1612-1619.1993
PMCID: PMC237532

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Autologous antibody response against the principal neutralizing domain of human immunodeficiency virus type 1 isolated from infected humans.PMID 8437232Read ↗

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