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Article

Structure-function of the putative I-domain within the integrin beta 2 subunit.

The Journal of biological chemistry - 1 Jun 2001

Xiong Y M, Zhang L

Abstract excerpt

The central region (residues 125-385) of the integrin beta(2) subunit is postulated to adopt an I-domain-like fold (the beta(2)I-domain) and to play a critical role in ligand binding and heterodimer formation. To understand structure-function relationships of this region of beta(2), a homolog-scanning mutagenesis approach, which entails substitution of nonconserved hydrophilic sequences within the beta(2)I-domain...

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PMID: 11278448
DOI: 10.1074/jbc.M008903200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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