Article
Mutational analysis of the CD2/CD58 interaction: the binding site for CD58 lies on one face of the first domain of human CD2.
The Journal of experimental medicine - 1 Aug 1993
Somoza C, Driscoll P C, Cyster J G, Williams A F
Abstract excerpt
The adhesion interaction between the immunoglobulin superfamily molecules CD2 and CD58 (lymphocyte function-associated antigen 3) plays an important role in T cell and natural killer cell interaction with various antigen-presenting and target cells. Determination of the solution structure of rat...
Topics
- Amino Acid Sequence
- Animals
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Binding Sites
- CD2 Antigens
- CD58 Antigens
- Cells, Cultured
- Computer Simulation
- Erythrocytes
- Humans
- Membrane Glycoproteins
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Rats
- Receptors, Immunologic