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Article

Stoichiometry of a recombinant GABAA receptor deduced from mutation-induced rectification.

Neuroreport - 13 Dec 1993

Backus K H, Arigoni M, Drescher U, Scheurer L, Malherbe P, Möhler H, Benson J A

Abstract excerpt

Ligand-gated ion channels generally display a heterooligomeric subunit structure. The present report describes an electrophysiological method that provides criteria indicating the subunit stoichiometry of a recombinant GABAA receptor composed of alpha 3, beta 2 and gamma 2 subunits. Our results exclude the stoichiometries 3 alpha 1 beta 1 gamma, 1 alpha 3 beta 1 gamma, 1 alpha 1 beta 3 gamma and suggest that the...

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PMID: 7507726
DOI: 10.1097/00001756-199312000-00026

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