Article
Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation.
Receptors & channels - 1 Jan 2003
Burzomato Valeria, Groot-Kormelink Paul J, Sivilotti Lucia G, Beato Marco
Abstract excerpt
Heteromeric glycine receptors mediate synaptic inhibition in the caudal areas of the adult mammalian central nervous system (CNS). These channels resemble other receptors in the nicotinic superfamily in that they are pentamers, but may differ in that they contain alpha and beta subunits in a 3:2 rather than a 2:3 ratio. Evidence in favor of a 3alpha:2beta stoichiometry of heteromeric glycine receptors comes from...
Topics
- Cell Line
- Central Nervous System Stimulants
- DNA, Complementary
- Dose-Response Relationship, Drug
- Electrophysiology
- Glycine
- Humans
- Mutagenesis, Site-Directed
- Mutation
- Picrotoxin
- Plasmids