V3 variability can influence the ability of an antibody to neutralize or enhance infection by diverse strains of human immunodeficiency virus type 1.

doi:10.1073/pnas.90.24.11518

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Article

V3 variability can influence the ability of an antibody to neutralize or enhance infection by diverse strains of human immunodeficiency virus type 1.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1993

Kliks S C, Shioda T, Haigwood N L, Levy J A

Abstract excerpt

Human monoclonal antibodies (mAbs) to two contiguous epitopes in the V3 loop of the human immunodeficiency virus type 1 (HIV-1) envelope have shown different effects on three distinct strains of the virus: neutralization, enhancement, or resistance to both processes. Only one amino acid in the mA...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
CHO Cells
Cricetinae
Enzyme-Linked Immunosorbent Assay
Epitopes
Genetic Variation
HIV Antibodies
HIV Antigens
HIV Envelope Protein gp120

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV Seronegativity

HIV Seropositivity

HIV-1

Humans

Molecular Sequence Data

Neutralization Tests

Papio

Source

Open in PubMed Open full text

Identifiers

PMID: 7505441
DOI: 10.1073/pnas.90.24.11518
PMCID: PMC48015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7505441-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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