Article
A broad range of mutations in HIV-1 neutralizing human monoclonal antibodies specific for V2, V3, and the CD4 binding site.
Molecular immunology - 1 Aug 2015
Li Liuzhe, Wang Xiao-Hong, Williams Constance, Volsky Barbara, Steczko Olivia, Seaman Michael S, Luthra Kalpana, Nyambi Phillipe, Nadas Arthur, Giudicelli Véronique, Lefranc Marie-Paule, Zolla-Pazner Susan, Gorny Miroslaw K
Abstract excerpt
The HIV vaccine-induced neutralizing antibodies (Abs) display low rates of mutation in their variable regions. To determine the range of neutralization mediated by similar human monoclonal Abs (mAbs) but derived from unselected chronically HIV-1 infected subjects, we tested a panel of 66 mAbs specific to V3, CD4 binding site (CD4bs) and V2 regions. The mAbs were tested against 41 pseudoviruses, including 15 tier...
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