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Article

Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody.

Journal of virology - 1 Dec 1992

Gorny M K, Conley A J, Karwowska S, Buchbinder A, Xu J Y, Emini E A, Koenig S, Zolla-Pazner S

Abstract excerpt

The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is thought to induce potent neutralizing antibodies which are generally defined as type specific and reactive with individual viral isolates. In contrast, the CD4-binding domain is thought to induce neutralizing antibodies that are group specific and capable of neutralizing all isolates of HIV-1. However, in this study, we used a panel of...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
CD4 Antigens
Cell Line
Enzyme-Linked Immunosorbent Assay
Genetic Variation
HIV Envelope Protein gp120
HIV-1
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutralization Tests

Protein Structure, Secondary

Source

Open in PubMed Open full text

Identifiers

PMID: 1433529
DOI: 10.1128/JVI.66.12.7538-7542.1992
PMCID: PMC240465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1433529-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody.PMID 1433529Read ↗

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