Article
Implication of HLA-DR residues at positions 67, 71, and 86 in interaction between HLA-DR11 and peptide HA306-320.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1993
Zeliszewski D, Golvano J J, Gaudebout P, Dorval I, Freidel C, Gebuhrer L, Betuel H, Borras-Cuesta F, Sterkers G
Abstract excerpt
To get further insight into the role of three polymorphic DR residues located in one alpha-helix of the HLA-DR binding groove, we studied how natural substitutions at positions 67, 71, and 86 on DR11 molecules influence MHC binding and/or T cell recognition of peptide HA306-320 and of monosubstituted peptide analogues. Our results show that: 1) Reactivities of all HA306-320-specific T cell clones tested are...
Topics
- Amino Acid Sequence
- Antigen Presentation
- Binding Sites
- Clone Cells
- Epitopes
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Humans