Article
Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived Hyp mice: a mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets.
Endocrinology - 1 Apr 1994
Roy S, Martel J, Ma S, Tenenhouse H S
Abstract excerpt
X-Linked Hyp mice exhibit rachitic bone disease, hypophosphatemia, impaired renal phosphate reabsorption, and abnormal regulation of renal 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] metabolism. We demonstrated that phosphate deprivation of Hyp mice, but not normal littermates, elicits a dramatic fal...
Topics
- Animals
- Calcitriol
- Cytochrome P-450 Enzyme System
- Female
- Genetic Linkage
- Hypophosphatemia
- Kidney
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- Phosphates
- RNA, Messenger
- Rickets
- Steroid Hydroxylases
- Vitamin D3 24-Hydroxylase
- X Chromosome