Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parathyroid hormone-related peptide is expressed and rapidly inducible in human liver cell cultures that have a bile duct phenotype.

Journal of hepatology - 1 Aug 1995

Roskams T, Moshage H, Depla E, Willems M, Desmet V, Yap P

Abstract excerpt

Parathyroid hormone-related peptide is the major factor responsible for hypercalcemia of malignancy. There is increasing evidence that parathyroid hormone-related peptide also plays an important role in the growth and differentiation of both neoplastic and non-neoplastic cells. Recently we found that reactive human bile ductules and cholangiocarcinomas, but not normal bile ducts, human hepatocytes nor...

Topics

Bile Ducts
Cell Division
Cell Line
Epithelial Cells
Epithelium
Gene Expression
Humans
Keratins
Parathyroid Hormone
Parathyroid Hormone-Related Protein
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Biosynthesis

Proteins

RNA, Messenger

Tumor Cells, Cultured

Source

Identifiers

PMID: 7499787
DOI: 10.1016/0168-8278(95)80330-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7499787-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parathyroid hormone-related peptide is expressed and rapidly inducible in human liver cell cultures that have a bile duct phenotype.PMID 7499787Read ↗

Parathyroid Hormone Related Protein (PTHrP)-Associated Molecular Signatures in Cell Signaling during Tissue Differentiation and in Non-tumoral DiseasesSemantic proximity Read ↗

Phenotypic characterization of rat hepatoma cell lines and lineage-specific regulation of gene expression by differentiation agents.Semantic proximity Read ↗

Cytokeratins and cell differentiation in the pancreasSemantic proximity Read ↗

In vitro differentiation of WB-F344 rat liver epithelial cells into the biliary lineage.Semantic proximity Read ↗

Modified culture conditions enhance expression of differentiated phenotypic properties of normal rat cholangiocytes.Semantic proximity Read ↗

Correlation of alpha-fetoprotein expression in normal hepatocytes during development with tyrosine phosphorylation and insulin receptor expression.Semantic proximity Read ↗

Effects of differentiation inducers on cell phenotypes of cultured nontransformed and immortalized mammary epithelial cells: a comparative immunocytochemical analysis.Semantic proximity Read ↗

Phenotypic characteristics and proliferative activity of hyperplastic ductule cells in cholangiofibrosis induced by thioacetamide in rats.Semantic proximity Read ↗

Gene expression in hepatocyte-like lines established by targeted carcinogenesis in transgenic mice.Semantic proximity Read ↗

Long-term culture and characteristics of normal rat liver bile duct epithelial cells.Semantic proximity Read ↗

Internal Radiotherapy of Liver Cancer with Rat Hepatocarcinoma-Intestine-Pancreas Gene as a Liver Tumor-Specific PromoterSemantic proximity Read ↗

Diagnostic implications of albumin messenger RNA detection and cytokeratin pattern in benign hepatic lesions and biliary cystadenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.