Article
Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.
Molecular cell - 18 Jun 2015
Gaubitz Christl, Oliveira Taiana M, Prouteau Manoel, Leitner Alexander, Karuppasamy Manikandan, Konstantinidou Georgia, Rispal Delphine, Eltschinger Sandra, Robinson Graham C, Thore Stéphane, Aebersold Ruedi, Schaffitzel Christiane, Loewith Robbie
Abstract excerpt
Target of Rapamycin (TOR) plays central roles in the regulation of eukaryote growth as the hub of two essential multiprotein complexes: TORC1, which is rapamycin-sensitive, and the lesser characterized TORC2, which is not. TORC2 is a key regulator of lipid biosynthesis and Akt-mediated survival signaling. In spite of its importance, its structure and the molecular basis of its rapamycin insensitivity are unknown....
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