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Article

Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site.

Genes & development - 1 Dec 1995

Ashe M P, Griffin P, James W, Proudfoot N J

Abstract excerpt

In common with all retroviruses, the human immunodeficiency virus type 1 (HIV-1) contains duplicated long terminal repeat (LTR) sequences flanking the proviral genome. These LTRs contain identical poly(A) signals, which are both transcribed into RNA. Therefore, to allow efficient viral expression, a mechanism must exist to either restrict promoter-proximal poly(A) site use or enhance the activity of the...

Topics

Base Sequence
Binding, Competitive
Gene Expression Regulation
HIV Long Terminal Repeat
HIV-1
Humans
Molecular Sequence Data
Mutation
Poly A
Promoter Regions, Genetic
Proviruses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splicing

RNA, Messenger

Transcription, Genetic

Source

Identifiers

PMID: 7498796
DOI: 10.1101/gad.9.23.3008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7498796-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site.PMID 7498796Read ↗

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