Biological importance and cooperativity of HIV-1 regulatory gene splice acceptors.

doi:10.1006/viro.1994.1342

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Article

Biological importance and cooperativity of HIV-1 regulatory gene splice acceptors.

Virology - 1 Jul 1994

Riggs N L, Little S J, Richman D D, Guatelli J C

Abstract excerpt

The replication of HIV-1 mutants containing altered splice acceptor sequences was studied. The splice acceptor sites 5' of the essential tat and rev AUG codons were altered to eliminate specifically spliced species from the viral repertoire of mRNAs. All splice site mutants were attenuated or fully defective. Mutation of the tat splice acceptor (exon 4) caused loss of the mRNA species containing exon 4 and...

Topics

Cell Line
Cloning, Molecular
Codon
DNA, Viral
Genes, Regulator
Genes, Viral
Genes, rev
Genes, tat
Genetic Complementation Test
HIV-1
Mutagenesis
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

RNA Splicing

RNA, Messenger

RNA, Viral

Viral Structural Proteins

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 8009838
DOI: 10.1006/viro.1994.1342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8009838-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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