Stem-loop 1 of the U1 snRNP plays a critical role in the suppression of HIV-1 polyadenylation

doi:10.1017/s1355838200991957

Article

Stem-loop 1 of the U1 snRNP plays a critical role in the suppression of HIV-1 polyadenylation

1 Feb 2000

Abstract excerpt

The inactivity or occlusion of the HIV-1 poly(A) signal when in the 5' long terminal repeat (LTR) has been mechanistically investigated. First we show that neither the homologous HIV-1 promoter nor the close proximity of this RNA processing signal to the transcript initiation site is required for the occlusion effect. Instead we demonstrate that the major splice donor (MSD) site positioned about 200 bp downstream...

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