Suppression analysis reveals a functional difference between the serines in positions two and five in the consensus sequence of the C-terminal domain of yeast RNA polymerase II.

doi:10.1093/genetics/143.2.661

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Article

Suppression analysis reveals a functional difference between the serines in positions two and five in the consensus sequence of the C-terminal domain of yeast RNA polymerase II.

Genetics - 1 Jun 1996

Yuryev A, Corden J L

Abstract excerpt

The largest subunit of RNA polymerase II contains a repetitive C-terminal domain (CTD) consisting of tandem repeats of the consenus sequence Tyr1Ser2Pro3Thr4Ser5Pro6Ser7. Substitution of nonphosphorylatable amino acids at positions two or five of the Saccharomyces cerevisiae CTD is lethal. We dev...

Topics

Mutation
RNA Polymerase II
Repetitive Sequences, Nucleic Acid
Saccharomyces cerevisiae
Sequence Analysis
Serine
Suppression, Genetic

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