Ethnic differences in the associations between the HLA-DRB1*04 subtypes and type 1 diabetes.

doi:10.1196/annals.1288.047

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Article

Ethnic differences in the associations between the HLA-DRB1*04 subtypes and type 1 diabetes.

Annals of the New York Academy of Sciences - 1 Nov 2003

Rewers Amanda, Babu Sunanda, Wang Tian Bao, Bugawan Teodorica L, Barriga Kathy, Eisenbarth George S, Erlich Henry A

Abstract excerpt

The HLA genotype DRB1*03,DQB1*0201/DRB1*04,DQB1*0302 confers a 25-fold increase in the risk of type 1 diabetes. In persons with this genotype, DRB1*0405, *0402, and *0401 subtypes have been reported to further increase risk, whereas the *0403 and *0406 alleles confer a relative protection. We compared the frequencies of the DRB1*04 alleles in 193 type 1 diabetic patients with the...

Topics

Alleles
Case-Control Studies
Child
Diabetes Mellitus, Type 1
Ethnicity
HLA-DR Antigens
HLA-DRB1 Chains
Humans

Source

Open in PubMed

Identifiers

PMID: 14679080
DOI: 10.1196/annals.1288.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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