Association of the core clustering mutations (codon 21-34) and the severity of chronic hepatitis B in Korean patients.

Abstract excerpt

OBJECTIVES: There are regions in the core gene of hepatitis B virus (HBV) where missense mutations are clustered, and mutations in that region are related to severe liver disease. However, there were some differences of the major regions for mutation clustering among ethnic groups. To explore the phenomenon of clustering mutations in Korean patients with chronic HBV infection and to elucidate the correlation...

Topics

• Adult
• Base Sequence
• Chronic Disease
• Codon
• Female
• Genes, Viral
• Hepatitis B
• Hepatitis B virus
• Humans
• Korea
• Male
• Middle Aged