Article
Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast.
The Journal of biological chemistry - 8 Dec 1995
Kumar S, McLaughlin M M, McDonnell P C, Lee J C, Livi G P, Young P R
Abstract excerpt
CSBP1 and CSBP2 are human homologues of the Saccharomyces cerevisiae Hog1 mitogen-activated protein kinase which is required for growth in high osmolarity media. Expression of CSBP1, but not CSBP2, complemented a hog1 delta phenotype. A CSBP2 mutant (A34V) that complements hog1 delta was isolated and found to have approximately 3-fold lower kinase activity than the wild-type CSBP2. Further analysis revealed that...
Topics
- Base Sequence
- Calcium-Calmodulin-Dependent Protein Kinases
- Enzyme Activation
- Humans
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data
- Mutation
- Phenotype
- Saccharomyces cerevisiae Proteins