Article
MAPKKK-independent regulation of the Hog1 stress-activated protein kinase in Candida albicans.
The Journal of biological chemistry - 9 Dec 2011
Cheetham Jill, MacCallum Donna M, Doris Kathryn S, da Silva Dantas Alessandra, Scorfield Susan, Odds Frank, Smith Deborah A, Quinn Janet
Abstract excerpt
The Hog1 stress-activated protein kinase regulates both stress responses and morphogenesis in Candida albicans and is essential for the virulence of this major human pathogen. Stress-induced Hog1 phosphorylation is regulated by the upstream MAPKK, Pbs2, which in turn is regulated by the MAPKKK, Ssk2. Here, we have investigated the role of phosphorylation of Hog1 and Pbs2 in Hog1-mediated processes in C. albicans....
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