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Article

Evidence that the MAPK-docking site in MAPKK Dpbs2p is essential for its function.

Biochemical and biophysical research communications - 28 Jul 2006

Sharma Pratima, Mondal Alok K

Abstract excerpt

In eukaryotes, mitogen-activated protein kinase (MAPK) pathways are very important signal transduction modules that regulate various cellular processes. Although eukaryotic cells possess a number of MAP kinase pathways, normally the MAPKKs selectively activate their cognate MAPK. Recent studies suggest that the MAPK-docking site in MAPKK facilitates this specific recognition and activation. However, the role of...

Topics

Binding Sites
Fungal Proteins
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Mutation
Phosphorylation
Protein Binding
Protein Structure, Tertiary
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Saccharomycetales

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Identifiers

PMID: 16765917
DOI: 10.1016/j.bbrc.2006.05.155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16765917-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Evidence that the MAPK-docking site in MAPKK Dpbs2p is essential for its function.PMID 16765917Read ↗

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Osmostress induces autophosphorylation of Hog1 via a C-terminal regulatory region that is conserved in p38α.Semantic proximity Read ↗

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.Semantic proximity Read ↗

Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.Semantic proximity Read ↗

A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.Semantic proximity Read ↗

MAPKKK-independent regulation of the Hog1 stress-activated protein kinase in Candida albicans.Semantic proximity Read ↗

Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.Semantic proximity Read ↗

Identifying protein kinase-specific effectors of the osmostress response in yeast.Semantic proximity Read ↗

Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast.Semantic proximity Read ↗

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Ssk1p-independent activation of Ssk2p plays an important role in the osmotic stress response in Saccharomyces cerevisiae: alternative activation of Ssk2p in osmotic stress.Semantic proximity Read ↗

Analyses of the effects of Rck2p mutants on Pbs2pDD-induced toxicity in Saccharomyces cerevisiae identify a MAP kinase docking motif, and unexpected functional inactivation due to acidic substitution of T379.Semantic proximity Read ↗

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