Article
Alterations of the TP53 gene as a potential prognostic marker in breast carcinomas. Advantages of using constant denaturant gel electrophoresis in mutation detection.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Sept 1995
Andersen T I, Børresen A L
Abstract excerpt
Reviewing studies of alterations of the TP53 tumor suppressor gene in human breast carcinomas gives cautious optimism about TP53 alterations as a prognostic marker in this disease. For the time being, breast carcinomas should be screened for TP53 alterations at both the protein and gene levels. I...
Topics
- Base Sequence
- Biomarkers, Tumor
- Breast Neoplasms
- Carcinoma
- Electrophoresis, Polyacrylamide Gel
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Denaturation
- Polymerase Chain Reaction
- Prognosis
- Tumor Suppressor Protein p53