Alterations of the TP53 gene as a potential prognostic marker in breast carcinomas. Advantages of using constant denaturant gel electrophoresis in mutation detection.

Abstract excerpt

Reviewing studies of alterations of the TP53 tumor suppressor gene in human breast carcinomas gives cautious optimism about TP53 alterations as a prognostic marker in this disease. For the time being, breast carcinomas should be screened for TP53 alterations at both the protein and gene levels. Improved mutational screening techniques are needed for this purpose. We consider constant denaturant gel...

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