Article
Screening for germ line TP53 mutations in breast cancer patients.
Cancer research - 1 Jun 1992
Børresen A L, Andersen T I, Garber J, Barbier-Piraux N, Thorlacius S, Eyfjörd J, Ottestad L, Smith-Sørensen B, Hovig E, Malkin D
Abstract excerpt
The constant denaturant gel electrophoresis technique was used to screen for TP53 germ line mutations in 237 women with breast carcinoma (167 unselected patients, 30 patients with at least one first-degree relative with breast cancer, and 40 women diagnosed with breast cancer before age 35). A germ line mutation at codon 181 was noted in one of the unselected patients and a codon 245 mutation in one of the...
Topics
- Adult
- Base Sequence
- Breast Neoplasms
- Codon
- Female
- Genes, Tumor Suppressor
- Humans
- Iceland
- Male
- Middle Aged
- Mutation
- Norway