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Article

Effects of zinc finger mutations on the nucleic acid binding activities of Xenopus transcription factor IIIA.

Biochemistry - 28 Nov 1995

Zang W Q, Veldhoen N, Romaniuk P J

Abstract excerpt

Transcription factor IIIA (TFIIIA) is required for the activation of 5S RNA gene transcription as well as the storage of 5s RNA as a 7S ribonucleoprotein particle. Interaction with both nucleic acids is mediated through nine C2H2 zinc fingers. In order to determine amino acid regions necessary for nucleic acid interaction, a series of substitution mutants Xenopus laevis TFIIIA have been constructed and expressed...

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Identifiers

PMID: 7492557
DOI: 10.1021/bi00047a021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of zinc finger mutations on the nucleic acid binding activities of Xenopus transcription factor IIIA.PMID 7492557Read ↗

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Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein.Semantic proximity Read ↗

The effects of disrupting 5S RNA helical structures on the binding of Xenopus transcription factor IIIA.Semantic proximity Read ↗

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Interaction of the TFIIB zinc ribbon with RNA polymerase II.Semantic proximity Read ↗

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