Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

7 Jun 2010

Abstract excerpt

An account is given of the discovery of the classical Cys(2)His(2) zinc finger, arising from the interpretation of biochemical studies on the interaction of the Xenopus protein transcription factor IIIA with 5S RNA, and of structural studies on its structure and its interaction with DNA. The finger is a self-contained domain stabilized by a zinc ion ligated to a pair of cysteines and a pair of histidines, and by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Monoclonal and Polyclonal Antibodies Research
Share to RNA and protein synthesis mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20192761
DOI: 10.1146/annurev-biochem-010909-095056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome ManipulationPMID 20192761Read ↗

Custom DNA-binding proteins and artificial transcription factors.Semantic proximity Read ↗

Zinc Finger Nucleases as tools to understand and treat human diseasesSemantic proximity Read ↗

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoterSemantic proximity Read ↗

Chemically regulated zinc finger transcription factors.Semantic proximity Read ↗

Rational design, selection and specificity of artificial transcription factors (ATFs): the influence of chromatin in target gene regulation.Semantic proximity Read ↗

Building zinc fingers by selection: toward a therapeutic application.Semantic proximity Read ↗

Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains.Semantic proximity Read ↗

Development of Zinc Finger Domains for Recognition of the 5′-ANN-3′ Family of DNA Sequences and Their Use in the Construction of Artificial Transcription FactorsSemantic proximity Read ↗

Design, construction and in vitro testing of zinc finger nucleasesSemantic proximity Read ↗

Highly efficient endogenous human gene correction using designed zinc-finger nucleases.Semantic proximity Read ↗

<i>In vitro</i> selection of Engineered Transcriptional Repressors for targeted epigenetic silencing and initial evaluation of their specificity profileSemantic proximity Read ↗

Emerging gene knockout technology in zebrafish: zinc-finger nucleases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.