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Article

Genetic control of the CD4/CD8 T-cell ratio in humans.

Nature medicine - 1 Dec 1995

Amadori A, Zamarchi R, De Silvestro G, Forza G, Cavatton G, Danieli G A, Clementi M, Chieco-Bianchi L

Abstract excerpt

We studied the genetic pattern of inheritance of the ratio between circulating CD4+ and CD8+ T lymphocytes in a population of healthy donors. The distribution of the CD4/CD8 ratio in males and females was significantly different and was significantly affected by age. In 46 randomly selected families, the parental CD4/CD8 ratio significantly influenced the ratio in offspring. Complex segregation analysis of the...

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PMID: 7489409
DOI: 10.1038/nm1295-1279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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