Involvement of the major histocompatibility complex region in the genetic regulation of circulating CD8 T-cell numbers in humans.

doi:10.1111/j.1399-0039.2004.00245.x

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Article

Involvement of the major histocompatibility complex region in the genetic regulation of circulating CD8 T-cell numbers in humans.

Tissue antigens - 1 Jul 2004

Cruz E, Vieira J, Gonçalves R, Alves H, Almeida S, Rodrigues P, Lacerda R, Porto G

Abstract excerpt

Variability in T-lymphocyte numbers is partially explained by a genetic regulation. From studies in animal models, it is known that the Major Histocompatibility Complex (MHC) is involved in this regulation. In humans, this has not been shown yet. The objective of the present study was to test the hypothesis that genes in the MHC region influence the regulation of T-lymphocyte numbers. Two approaches were used....

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Animals
CD8-Positive T-Lymphocytes
Female
Gene Frequency
Genotype
HLA-A Antigens
HLA-B Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hemochromatosis

Hemochromatosis Protein

Histocompatibility Antigens Class I

Humans

Lymphocyte Count

Major Histocompatibility Complex

Source

Open in PubMed

Identifiers

PMID: 15191520
DOI: 10.1111/j.1399-0039.2004.00245.x

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