Article
Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations.
American journal of human genetics - 1 May 2002
Hall M A, Norman P J, Thiel B, Tiwari H, Peiffer A, Vaughan R W, Prescott S, Leppert M, Schork N J, Lanchbury J S
Abstract excerpt
Lymphocyte subpopulation levels are used for prognosis and monitoring of a variety of human diseases, especially those with an infectious etiology. As a primary step to defining the major gene variation underlying these phenotypes, we conducted the first whole-genome screen for quantitative variation in lymphocyte count, CD4 T cell, CD8 T cell, B cell, and natural killer cell numbers, as well as CD4:CD8 ratio....
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