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Article

Environmental and genetic factors shape the human T-cell receptor repertoire.

Annals of the New York Academy of Sciences - 7 Jul 1995

Posnett D N

Abstract excerpt

Both environmental and genetic factors combine to shape the TCR repertoire as measured by V gene usage. These factors may result in dramatic shifts in normal subjects, which cannot be discounted when studies are performed in patients with disease. Future studies need to explore further examples of genetic and environmental factors that shape the TCR repertoire to understand the full extent of variation in a...

Topics

Alleles
Animals
Base Sequence
Clone Cells
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Humans
Mice
Molecular Sequence Data
Point Mutation
Receptors, Antigen, T-Cell, alpha-beta
Receptors, Antigen, T-Cell, gamma-delta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Source

Identifiers

PMID: 7645876
DOI: 10.1111/j.1749-6632.1995.tb44483.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7645876-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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