Article
Marker genes for cytotoxic exposure: p53.
Stem cells (Dayton, Ohio) - 1 May 1995
Montenarh M
Abstract excerpt
The growth suppressor p53 plays an important role in the regulation of cell proliferation, DNA repair and apoptosis. In wild-type p53 expressing cells, gamma-irradiation induces an increase in the level of p53 protein and these cells exhibit a G1 growth arrest. The p53-induced G1 growth arrest is abrogated in cells expressing mutant p53, or in cells where p53 is inactivated by complex formation with cellular or...
Topics
- Animals
- Cells, Cultured
- DNA
- DNA Damage
- G1 Phase
- Genes, p53
- Genetic Markers
- Humans
- Mutation
- Radiation Tolerance