Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Restoration of p53 Expression in Human Cancer Cell Lines Upregulates the Expression of Notch1: Implications for Cancer Cell Fate Determination after Genotoxic Stress

1 May 2007

Abstract excerpt

Following genotoxic stress, transcriptional activation of target genes by p53 tumor suppressor is critical in cell fate determination. Here we report that the restoration of p53 function in human cancer cell lines that are deficient in p53 function upregulated the expression of Notch1. Interestingly, the expression of wild-type p53 in human prostate and breast cancer cell lines correlated well with increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Developmental Biology and Gene Regulation
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17534448
DOI: 10.1593/neo.07211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restoration of p53 Expression in Human Cancer Cell Lines Upregulates the Expression of Notch1: Implications for Cancer Cell Fate Determination after Genotoxic StressPMID 17534448Read ↗

P53: a determinant of the cell cycle response to DNA damage.Semantic proximity Read ↗

ΔNp63α Repression of the <i>Notch1</i> Gene Supports the Proliferative Capacity of Normal Human Keratinocytes and Cervical Cancer CellsSemantic proximity Read ↗

Regulation of Notch1 Gene Expression by p53 in Epithelial CellsSemantic proximity Read ↗

Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress responseSemantic proximity Read ↗

Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53Semantic proximity Read ↗

A dominant negative form of p63 inhibits apoptosis in a p53-independent manner.Semantic proximity Read ↗

Comparison of genotoxic vs. non-genotoxic stabilization of p53 provides insight into parallel stress-responsive transcriptional networksSemantic proximity Read ↗

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.Semantic proximity Read ↗

Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA DamageSemantic proximity Read ↗

p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3Semantic proximity Read ↗

A new genotoxicity assay based on p53 target gene induction.Semantic proximity Read ↗

p53-independent apoptosis limits DNA damage-induced aneuploidy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.