Identification of V3 mutations that can compensate for inactivating mutations in C4 of simian immunodeficiency virus.

doi:10.1006/viro.1995.1558

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Article

Identification of V3 mutations that can compensate for inactivating mutations in C4 of simian immunodeficiency virus.

Virology - 20 Oct 1995

Kirchhoff F, Morrison H G, Desrosiers R C

Abstract excerpt

A valine to isoleucine substitution at position 322 within variable region 3 (V3) of envelope of simian immunodeficiency virus was previously shown to compensate for an inactivating valine to glycine mutation at position 448 in constant region 4 (C4) (Morrison et al., Virology 195, 167-174, 1993). Cloned DNA fragments with inactivating C4 mutations were combined with complex mixtures of mutant V3 sequences, and...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cells, Cultured
Chlorocebus aethiops
Genes, env
Kidney
Leukocytes, Mononuclear
Macaca mulatta
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Mutation

Simian Immunodeficiency Virus

T-Lymphocytes

Transfection

Viral Envelope Proteins

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 7483261
DOI: 10.1006/viro.1995.1558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7483261-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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